One area of recent investigation for psychiatric disorder treatment is inducing ketogenesis, either vis dietary changes (i.e., natural ketosis) or the use of supplements (i.e., endogenous ketone supplementation). Ketone diets and exogenous ketone supplementation look to achieve a state of natural ketosis (NK). During a state of NK, certain ketone bodies replace carbohydrates as fuel to the brain and other organs. 

Ketones & Psychiatric Help

Ketogenic diets feature high-fat, adequate-protein, and very low carbohydrate foods and beverages, and from historical accounts may have an alleviating effect on some psychiatric conditions. Research has suggested bioenergetics and ketosis may have effects on neuronal activity, neurotransmitter balance, and inflammatory processes.  

Unfortunately, strict patient compliance with ketogenic diets is necessary to achieve therapeutic ketosis. Adherence to these diets can be difficult or impossible for most people. Ketogenic diets typically need to be overseen by a medical professional, which can be unaffordable or even unavailable for some people.

Potential Psychiatric Benefits of Ketones

A ketogenic diet could potentially lead to numerous benefits for patients suffering from certain psychiatric disorders. The fact that an unmonitored keto diet would likely have low compliance makes it difficult to implement as a successful intervention, or to study in a larger-scale research setting. Strict adherence and oversight are required for a keto diet to succeed, something that can be very hard to achieve in clinical practice or the general population.

The potential for positive effects of a ketogenic diet on psychiatric disorders, however, has led to many smaller-scale studies. Different psychiatric conditions may react differently to ketogenic diets, which is why many modern studies focus on specific conditions.  Psychiatric disorders that are under investigation with ketogenic diets include:

• Anxiety disorders

• Major depressive disorder
• ADHD
• Bipolar disorder
• Schizophrenia

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